郭非凡
郭非凡
个人简介：
郭非凡博士1992年毕业于大连医科大学临床医学系，于1995年在大连医科大学获得病理生理学专业硕士，2001年获得日本东京大学神经生化学博士。2001年至2005年分别在美国明尼苏达州立大学和哈佛大学医学院Beth Israel Deaconess医学中心从事博士后研究工作。2005年至2007任美国宾州州立大学研究助理教授。2007年至今聘为中国科学院上海生命科学研究院营养科学研究所研究员，研究组长。
研究领域：
该研究组主要是通过生化和分子细胞生物学方法，在细胞和动物水平阐明遗传和营养调节的诸如肥胖、糖尿病和脂肪肝等代谢疾病的分子机制。目前研究集中在中枢神经系统和外周神经系统对亮氨酸缺乏引起的脂肪代谢异常的研究上。该研究将对肥胖、糖尿病和脂肪肝的营养学干预和治疗提供依据和可能。
近期论文：
Du Y, Meng Q, Zhang Q, Guo F*. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. Amino Acids. 2011 Oct 21. [Epub ahead of print]
Cheng Y#, Zhang Q# (co-author), Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, and Guo F*. Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in The Hypothalamus and Activating The Sympathetic Nervous System. Molecular Endocrinology. 2011, 25(9):1624-1635.
Li H, Meng Q, Xiao F, Chen S, Yu J, Wang C, and Guo F*. ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis. Biochemical Journal. 2011, 438(2):283-289.
Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, and Guo F*. Leucine Deprivation Increases Hepatic Insulin Sensitivity Via GCN2/mTOR/S6K1 and AMPK Pathways. Diabetes. 2011, 60: 746-756.
Zhang Q, Li H and Guo F*. Amygdala, an important regulator for food intake (Invited Review). Frontiers in Biology. 2011, 6: 82-85.
Cheng Y#, Meng Q# (co-author), Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*. Leucine deprivation decreases fat mass by stimulation of lipolysis in WAT and upregulation of UCP1 in BAT. Diabetes. 2010, 59: 17-25.
Wang C, Huang Z, Du Y, Cheng Y, Chen S and Guo F*. ATF4 regulates lipid metabolism and thermogenesis. Cell Research. 2010, 20:174-184.
Guo F, Cavener D. The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid. Cell Metabolism. 2007, 5:103-114.
Ebihara T, Guo F, Zhang L, Kim JY, Saffen D. Muscarinic acetylcholine receptors stimulate Ca2+ influx in PC12D cells predominantly via activation of Ca2+ store-operated channels. The Journal of Biochemistry. 2006, 139: 449-458.
Zhang L, Guo F, Kim J, Saffen D. Muscarinic Acetylcholine Receptors Activate TRPC6 Channels in PC12D Cells via Ca2+ Store–Independent Mechanisms. The Journal of Biochemistry. 2006, 139: 459-470.