梁德生
梁德生
梁德生，男，1962年生，医学遗传学博士，教授。现任中南大学中国医学遗传学国家重点实验室副主任，国家生命科学与技术人才培养基地-基因科学与技术产业化点主任，中南大学湘雅医院产前诊断中心副主任。2005年3月起任日本国立长崎大学医学院邀请/访问教授。兼任湖南省遗传学会副理事长。主要负责基因治疗、人类遗传资源的收集、保藏和共享、染色体病防治、遗传病诊断与产前诊断和“基地”教学及产业化工作。
梁德生
2004年至今，主持国家“973”和“863”计划课题各1项，主持或参加国家和部级重大科研计划课题5项；获2005年度国家科技进步奖二等奖1项，省部级科技进步奖各4项；发表论文40余篇，其中SCI收录论文20篇。2004年参加完成“角膜环状皮样瘤”致病基因的克隆；2005年发现了一个新的近端三体12p综合征并阐明染色体畸变的来源和发生机制；2006年参加完成国际合作研究项目“人类耳垢性状基因的克隆”，论文在Nature Genetics上发表；2007年1月“人源基因载体在血友病A基因治疗的应用研究”取得重要进展；2007年4月在国际上率先定位“人类4型并指/趾”致病位点。
主要科研项目
遗传病的基因治疗
中国人类染色体异常核型遗传资源的收集、保藏和利用
中国人类遗传疾病资源信息整理整合共享平台，教育部重大项目资助计划
染色体畸变发生机制及其遗传学效应，国家科技攻关计划
遗传病家系和肿瘤样本资源的收集及其数据库建设，国家高技术发展计划
遗传病家系收集、基因定位、基因克隆、基因功能研究和基因治疗，“长江学者”科学创新团队计划， 人类染色体异常核型资源的收集、保藏与利用，中南大学科学研究基金项目主要成果/奖励
世界首报中国人染色体异常核型遗传资源保藏及其B/S共享模式，2005年，中华人民共和国科学技术进步奖二等奖
脆性X综合征的遗传学研究，2003年，广东省科学技术进步奖三等奖
显微切割、探针池和FISH技术对染色体异常来源的研究，1996年，广东省科学技术进步奖三等奖
4500名儿童青少年动脉粥样硬化危险因子调查研究，1995年，广东省科学技术进步奖三等奖
中国南方人A型行为类型常模调查研究，1994年，全国爱卫会、卫生部科学技术进步奖三等奖
主要论文
Peer review publications (since 2004):
1. Sato D*, Liang D*, Wu L, Pan Q, Xia K, Dai H, Wang H, Nishimura G, Yoshiura KI, Xia J, Niikawa N. A syndactyly type IV locus maps to 7q36. J Hum Genet. 2007 May 3; [Epub ahead of print] (*co-author)
2. Hu H, Wu L, Feng Y, Pan Q, Long Z, Li J, Dai H, Xia K, Liang D , Niikawa N, Xia J. Molecular analysis of hearing loss associated with enlarged vestibular aqueduct in the mainland Chinese: a unique SLC26A4 mutation spectrum. J Hum Genet. 2007 Apr 19; [Epub ahead of print] (correspondent)
3. Liang Z, Luo H, Yang YF, Liu XH, Xie L, Xue ZG, Hu DX, Liang DS, Xia K, Xia JH. Targeted expression of vascular endothelial growth factor 165 in the hrDNA locus mediated by hrDNA targeting vector. Chin Med J (Engl). 2007 Mar 5; 120(5): 355-358.
4. Liu X, Liu M, Xue Z, Pan Q, Wu L, Long Z, Xia K, Liang D , Xia J. Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector. J Thromb Haemost. 2007 Feb;5(2):347-51. (correspondent)
5. Wang Lina, Xue Zhigang, Li Zhuo, Xue Jinfeng, Liu Xionghao, Pan Qian, Long Zhigao, Cai Fang, Wu Lingqian, Dai Heping, Xia Kun, Liang Desheng and Xia Jiahui. Investigation of hrDNA targeting vector-mediated tumor-specific suicide gene therapy for hepatocellular carcinoma. Chinese Science Bulletin 2006 Oct 5; 51(19): 2342-2350.
6. Zhu HY, Wu LQ, Pan Q, Liang DS, Long ZG, Dai HP, Xia K, Xia JH. Analysis of PAX6 gene in a Chinese aniridia family. Chin Med J (Engl). 2006 Aug 20; 119(16): 1400-2.
7. Zhu HY, Wu LQ, Pan Q, Tang BS, Liang DS, Long ZG, Dai HP, Xia K, Xia JH. Rapid genetic diagnosis and prenatal diagnosis of spinal muscular atrophy by denaturing high-performance liquid chromatography. Chin Med J (Engl). 2006 Jul 20; 119(14): 1222-5.
8. Xie ZG, Hu ZM, Pan Q, Zhang RF, Liang DS , Wu LQ, Long ZG, Dai HP, Xia K, Xia JH. A mutation 1633-26(C-->A) in EXT1 gene causes multiple exostoses. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Apr;23(2):147-50. Chinese. (correspondent)
9. Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko VA, Alipov GK, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano CK, Ghadami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray JC, Saito S, Nakamura Y, Niikawa N. A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet. 2006 Mar;38(3):324-30. Epub 2006 Jan 29.
10. Liang D, Wu L, Pan Q, Harada N, Long Z, Xia K, Yoshiura K, Dai H, Niikawa N, Cai F, Xia J. A father and son with mental retardation, a characteristic face, inv(12), and insertion trisomy 12p12.3-p11.2. Am J Med Genet A. 2006 Feb 1; 140 (3):238-44.
11. XUE Zhigang*, LIANG Desheng*, LONG Zhigao, PAN Qian, LIU Xionghao, WU Lingqian, CAI Fang, DAI Heping, XIA Kun & XIA Jiahui. Silica nanoparticle is a possible safe carrier for gene therapy. Chinese Science Bulletin. 2005, 50 (1): 1-5. (*co-author)
12. Hu H, Wu LQ, Liang DS, Feng Y, Cai F, Xia K, Pan Q, Long ZG, Dai HP, Xia JH. Prenatal diagnosis of prelingual deafness by determination of SLC26A4 gene mutation. Zhonghua Fu Chan Ke Za Zhi. 2005 Sep;40(9):591-4.
13. Liang Y, Liang D, Xue Z, Long Z, Wu L, Pan Q, Hu Y, Dai H, Xia K, Xia J. A minidystrophin-EGFP fusion gene expressed in Cos-7 cells mediated by human source vector. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Oct 10;22(5):493-496.
14. Liu XH, Liu MJ, She H, Wen L, Xue ZG, Liang DS, Cai F, Pan Q, Long ZG, Wu LQ, Dai HP, Xia K, Xia JH. Targeted Expression of the Modified FVIII Using Targeting Vector of Human Ribosomal RNA Gene. Chinese Science Bulletin. 2005, 50(18):1972-1977.
15. He LQ, Liu Y, Cai F, Tan ZP, Pan Q, Liang DS, Long ZG, Wu LQ, Huang LQ, Dai HP, Xia K, Xia JH, Zhang ZH. Intracellular distribution, assembly and effect of disease-associated connexin 31 mutants in HeLa cells. Acta Biochim Biophys Sin (Shanghai). 2005 Aug;37(8):547-54.
16. Hu H, Liang D , Wu L, Feng Y, Cai F, Xia K, Pan Q, Long Z, Dai H, Xia J. Molecular analysis of SLC26A4 gene in a Chinese deafness family. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug;22(4):376-9. Chinese. (correspondent)
17. Zhang R, Zhu Z, Zhu H, Nguyen T, Yao F, Xia K, Liang D, Liu C. SNP Cutter: a comprehensive tool for SNP PCR-RFLP assay design. Nucleic Acids Res. 2005 Jul 1;33 (Web Server issue):W489-92.
18. He LQ, Cai F, Liu Y, Liu MJ, Tan ZP, Pan Q, Fang FY, Liang de S, Wu LQ, Long ZG, Dai HP, Xia K, Xia JH, Zhang ZH. Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways. Cell Res. 2005 Jun; 15(6): 455-64.
19. Deng XY, Cai F, Xia K, Pan Q, Long ZG, Wu LQ, Liang DS, et al. Identification of the Alternative Promoters of the KChIP4 Subfamily. Acta Biochim Biophys Sin (Shanghai). 2005 Apr;37(4):241-7.
20. Lyu QF, Wu LQ, Li YP, Pan Q, Liu DE, Xia K, Liang DS, Cai F, Long ZG, Dai HP, Xia JH. An improved mechanical technique for assisted hatching. Hum Reprod. 2005 Jun; 20(6):1619-23.
21. De-sheng Liang, et al. Phenotype Location on Chromosomes in a Patient With the Syndrome of Partial Trisomy 7p21.2→pter. Acta Genetica Sinica. 2005 Feb; 32(2):124-9.
22. Kun Xia, Desheng Liang, et al. A Novel Fusion Suicide Gene Yeast CDglyTK plays a Role in Radio-genetherapy of Nasopharyngeal Carcinoma. Cancer Gene Therapy. 2004 Dec;11(12):790-6.
23. Xia K, Wu LQ,Xi XH,Liu XP,Liang DS, Zheng D, Cai F, Pan Q, Long ZG, Dai HP,Hu ZM, Tang BS,Zang ZH, Xia JH. Mutation in PITX2 is associated with Ring Dermoid of the Cornea. Journal of Medical Genetics. 2004 Dec;41(12):e129.
24. Baorong Zhang, Kun Xia, Meiping Ding, Desheng Liang, et al. Confirmation and refinement of a genetic locus of congenital motor nystagmus in Xq26.3-q27. 1 in a Chinese family. Human Genetics. 2005 Jan;116(1-2):128-31.
25. Jiahui Xia, Kun Xia, Yong Feng,Aifa Tang, Yaoyun Tang, Linqiang Wu, Desheng Liang, Fang Cai,Qian Pan, Zhigao Long, Heping Dai, Yunyi Zhang, Suping Zhao, Zhuchu Chen.Combination of Suicide gene therapy and radiation enhances the killing of nasopharyngeal carcinoma xenographs. Journal of Radiation Research. 2004,45(2): 281-289.
26. De-sheng Liang, et al. Analysis of chromosomes and its phenotype location on a patient with the karyotype of 45,XX,-13/46,XX,r(13)/46,XX,r(13;13)/47,XX,2r(13)(p13q32.3). Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Aug; Vol21,No.4:392-394
著作:
《医学遗传学》